In this clip, something is described as being "as old of time". Except for time and perhaps the universe itself, this is impossible.

Sheldon goes to Penny's place of work to convince her to apologize to Leonard.

In this clip, Candace describes herself as being "heartless"; this is obviously meant figuratively, not literally.

In this clip, Candace has to answer a call and tells her mother she is "taking" it. This is an idiom; one does not "take" a call so much as they answer it.

After taking estrogen, Howard asks Raj if his body is changing.They figure it out with some unusual methods.