The Powerpuff Girls want to fit in school better and they beg the professor to make them a potion to make them older. The girls drink too much and become senior citizens. At the breakfast table, Buttercup's teeth fall out, Bubbles begins to lose her hearing, and Blossom becomes forgetful.
After smoking tobacco for quite some time, the gang (Robin, Lily, Ted, Marshall, and Barney) starts to have health issues. Lily's voice becomes hoarse, Ted is easily fatigued due to the reduced flow of oxygen in his blood stream, and Arthur Hobbs, in an extreme situation, has a heart attack.
The doctor explains to Stephen Hawking that Motor Neuron Disease is affecting his ability to use any muscle activity, such as speaking, walking, breathing, and swallowing. The signals that tell the muscles to move are disrupted, and the result is gradual muscle decay.