Amy briefly explains the roles of the prefrontal cortex, the limbic system, and the amygdala in the context of Penny and Leonard's relationship.

Derek is tasked with performing a risky surgical procedure in order to remove a spinal tumor from a patient. He and Meredith discuss the problem and potential solutions. During the discussion, Derek draws a diagram of the spine that illustrates the issue the patient is facing. Derek faces a dilemma: if he cuts the cord, he will kill the tumor, but the patient will lose function in both of his legs. Derek tries to find a way to cure the tumor without cutting the cord.

Beakman explains that shoes stink because of the bacteria on your feet. He uses a microscope to quickly show that there are bacteria everywhere and then a short animated clip to show how your feet produce oil and sweat that the bacteria eat. This creates smelly biproducts to make your feet stink. He then does a DIY bacteria growth experiment where he grows bacteria from his sweaty feet in a jar of gelatin.

Beakman explains how hair grows starting with the hair follicle, why hair falls out and why different hair is different lengths. He also explains why hair is not living and how hormones affect hair growth.

Beakman explains what pimples are by using an animated clip. He explains normal function of your pores and then how this can get turned into a pimple and what pus is. Then they explain how to prevent pimples.