Marge is put under a lot of stress with all of her responsibilities, which include solving the problems of the rest of the family. She gradually is negatively affected by all the stress and ultimately reaches her tipping point, causing her to put herself and Maggie in danger. Her handling of the situation suggests she has poor stress management skills.

What is cancer, and how does it start? Find out how genetics play a role, which types of cancer are the most prevalent, and what is being done to fight this deadly disease.

The effects of stress on heart function are shown while Homer talks to Mr. Burns. Homer dies but returns for the promise of some ham.

The Bears go to the movie theater and watch a film titled, Germs. Iced Bear and Grizzly find the movie to be mildly entertaining, while Panda gets paranoid and scared of germs. While in the subway, Panda visualizes the germs in the environment and how they spread.

Matthew talks to Mary about her marriage. He expresses his happiness that she has found a person who would be willing to do anything for her and indicates that he is in full support of her decision to marry Richard.