Susie sings a song about how germs travel and how you can prevent yourself from getting sick. The song is accompanied by visuals to help improve understanding.

After George offers the sick Man with the Yellow Hat a spoonful of soup, George goes to use the same spoon to eat some of the soup himself. The Man with the Yellow Hat cautions against this, as he explains how germs work and the importance of washing your hands.

Frank gets ready to eat an egg he's prepared when a monkey at the zoo takes it from him. He fights with the monkey to get the egg back, and despite how filthy it has gotten, he eats it.

In George's dream, him and Gnocchi must work against the malicious germs that want to infect Professor Wiseman.

Pam shares tips on preventing the spread of germs with the rest of the office. Her tips include washing your hands regularly, covering your sneezes and coughs, and staying home if you're sick. Dwight interjects with a claim that exposing yourself to germs keeps your body healthy. Everyone else shares their germs with Dwight as a result.