The gang realizes that "Fun Bobby" is always drinking- he drinks more than all of the friends and always has a drink in his hand. This is a telling sign of someone being an alcoholic.
Ross and Rachel are under the influence of alcohol when Joey enters the room. He asks for help convincing his ant twin to cooperate, and Ross volunteers to help. Shortly after, Ross loses balance and asks Joey if he is okay. Ross and Rachel's actions illustrate slower cognitive function and a distorted view of reality.
After smoking tobacco for quite some time, the gang (Robin, Lily, Ted, Marshall, and Barney) starts to have health issues. Lily's voice becomes hoarse, Ted is easily fatigued due to the reduced flow of oxygen in his blood stream, and Arthur Hobbs, in an extreme situation, has a heart attack.
This clip provides a brief overview of the history of alcohol. It mentions some of the civilizations that first produced it. It also explains the chemistry behind alcohol's mind-altering effects and ways in which alcohol has influenced human culture.