The boss, Miranda, is set to return to the office earlier than expected. This creates a cascade of stress for her employees to get the office organized, just as Miranda likes it. The stress falls especially on Miranda's assistant, who is tasked with organizing Miranda's schedule.
In this clip, Sheldon and company are upset at the Large Hadron Collider's lack of findings and proclaim that "science is dead." Penny explains to them how they need to avoid wallowing in self-pity and to be productive instead.
Tip and Oh are about to find Tip's mom when Oh tries to get Tip to run away with him. The Gorg are about to attack, and Oh tells Tip it is not safe to stay. Tip gets angry at him for wanting to leave and lying that he would help her find her mom until the end. Oh debates on staying but ultimately leaves.